Antioxidant Activity and Phytochemical Screening of Different Solvent Extracts Cluasena excavate burm F. (Rutaceae)

Now-a-days, there is an increased occurrence of various diseases like cardiovascular disease, neurological disorders, cancer, diabetes and autoimmune disease due to the presence of free radicals. Bandyopadhyay et al. [1]. Antioxidant is defined as the agent that neutralizes the effect produced by free radical Fang Y et al. [2]. The antioxidant can be classified into two categories, namely enzymatic and non-enzymatic. The enzymatic antioxidants are produced itself in our body, whereas most of nonenzymatic antioxidants are obtained from either natural plants or synthetics which are used for the treatment for various diseases Lee J et al. [3] and Cuzzocrea S et al. [4]. A number of side effects like liver damage and mutagenesis are associated with the use of antioxidants obtained from synthetic sources Grice HC [5]. Thus, researchers are exploring natural resources to find out newer and safer natural antioxidants. The potentially reactive derivatives of oxygen, attributed as reactive species (ROS), are continuously generated inside the human body. The generated ROS are detoxified by the antioxidants present in the body. However, overproduction of ROS and/or inadequate antioxidant defense can easily affect and persuade oxidative damage to various bimolecular, including proteins, lipids, Natural antioxidants lipoproteins and DNA. The WHO estimates that up to 80% of people still rely mainly on traditional remedies such as herbs for their medicine [6]. India has been identified as a major resourceful area in the traditional and alternative medicines globally. Multi-factorial health beneficial activity of these plant extracts has been attributed to multi-potent anti-oxidant, anti-microbial, anti-cancer, anti-ulcerative and antidiabetic properties. Several medicinal plants (Rasayana) have also been extensively used in the Indian traditional (Ayurveda) system of medicine for the treatment of number of diseases. Some of these plants have shown potent antioxidant activity. Kaur C et al. [7] and Aqil et al. [8]. The WHO estimates that up to 80% of people still rely mainly on traditional remedies such as herbs for their medicine Tripathi et al. [6].